startxref View other preventive measures for 2,4-toluene diisocyanate in WISER. Baltimore, MD: The Williams and Wilkins Co., p. 141. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Le National Toxicology Program (NTP, 2005) classifie le diisocyanate de toluène (mélange d'isomères) comme une substance raisonnablement anticipée cancérogène (R). EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. EC Number 209-544-5. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). # D-5836-02N. 1 15 U.S.C §2601 et seq. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. endobj (January 1986). %PDF-1.5 TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. 1989]. (April 1996). Main chemical and physical properties. Ambient (>5 °C) Safety Data Sheet SDS. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Hazardou s in case of skin contact (permeator). Email. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o 0000009752 00000 n Caution is advised. ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. Melting point. NZ Med J 63:642-647. Autres études. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. when handling these materials. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. * Many scientists believe there is no safe level of exposure to a carcinogen. Reduction in diisocyanate-related occupational asthma is primarily … Slightly hazardous in case of skin contact (corrosive). chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. 2,6-Toluene diisocyanate. Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. Gunter BJ [1975]. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Number of Components Comps. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Toluene & Its Chemical Uses. Toluene Safety Data Sheet according to Federal Register / Vol. [Handling Chemcials Safely 1980. p. 907]. 2 0 obj Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. For more detailed information, please visit ECHA C&L website … Reaction with water liberates carbon dioxide. %%EOF Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. * Many scientists believe there is no safe level of exposure to a carcinogen. Certified Reference Material. Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. ���Y? Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) 0000003741 00000 n Risk of fire and explosion as a result of … 0000001487 00000 n Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Methyl Isocyanate. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 0000012275 00000 n This is based on test results presently : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. Main properties/hazards . xref 0000001666 00000 n Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc.:,. 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